A tRNA with Oncogenic Capacity
نویسنده
چکیده
Overexpression of Brf1, a transcription factor of the RNA polymerase III apparatus, can transform cells in vitro and cause tumor formation in vivo. Marshall et al. (2008) now show that one of the transcriptional products of RNA polymerase III, the initiator tRNA(Met), mediates this effect, revealing an unexpected role for this tRNA in tumorigenesis.
منابع مشابه
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ورودعنوان ژورنال:
- Cell
دوره 133 شماره
صفحات -
تاریخ انتشار 2008